Since Tramadol has a semblance to narcotic-like substances, it is advised against using this medicine in case you have a history of drug or alcohol addiction. This warning is based on the incident in 2009 when The United States Food and Drug association sent a written notice to Johnson & Johnson. It was felt that the website endorsing the medicine had underplayed the addictive effects of Tramadol. Keeping the addictive nature of the medicine in mind, it is best kept at bay from patients of substance abuse.
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It is observed that in certain people Tramadol intake has resulted in seizures. However, the pattern suggests that such convulsions and seizures occur in people with a background of medical disorders preceding Tramadol consumption. It is noted that people who have sustained a head injury or suffer from a metabolic dysfunction are more likely to experience seizures. Use of certain medicines in conjunction with Tramadol could also be the reason for convulsions. Muscle relaxing medicine, antidepressants and medication for nausea can cause a reaction with Tramadol and lead to seizures and hence caution should be exercised prior to consumption of Tramadol.